Week 2 in the East Region features four matches from three of the four conferences — three matches on Saturday and one on Sunday.

On Saturday, East Region action begins with Old Dominion Cesena USA traveling to Hampton Roads to take on Virginia Beach City FC in the second Colonial Conference match of the season. This will be the first 2018 match for Old Dominion Cesena USA, while Virginia Beach played a scoreless draw against Legacy W76 last weekend. Kickoff is scheduled for 2 p.m. EDT at the Virginia Beach Sportsplex.

Cincinnati Sirens FC will begin their Ohio Valley Conference season as they host Columbus Eagles FC. The Columbus Eagles are fresh off a 2-0 win over AAFC Lumberjills last weekend.  Kickoff is scheduled for 5 p.m. EDT at Lakota West High School.

The first Mid-Atlantic Conference match of the year is the final East Region match Saturday. Lehigh Valley Tempest hosts Hershey Soccer Club in Allentown, Pennsylvania. Kickoff is 7 p.m. EDT at the Cedar Crest College Falconplex.

Reining Mid-Atlantic Conference champion Torch FC hosts the Philly Fever in the lone East Region match on Sunday. Both clubs are set to begin their respective seasons. Kickoff is scheduled for 3:30 p.m. at Palisades High School.

There is a midweek match in the East Region next week with the Fever hosting Lehigh Valley on Thursday night at 7 p.m. in Warminster, Pennsylvania.